Out of the 191 patients 83 (43%) were males and 108 (57%) were females with mean age of 42.3☑8.34 years. The objective of our study is to determine the BUN/Creatinine ratio in cholera patients with dehydration and renal insufficiency and amount of fluid replacement therapy given in a tertiary care hospital in Pakistan. Untreated cholera cases can have fatality rates above 50%. Cholera have been used including tetracycline, ampicillin, ciprofloxacin and trimethoprim- sulfamethoxazole. Antimicrobial therapy shortens the course of the illness. The treatment management of cholera revolves around the oral or Intravenous (I/V) replenishment of the lost fluid, which is the mainstay therapy for these patients. It is diagnosed by Stool culture and agglutination of vibrios with specific sera. The common symptom associated with cholera is acute, painless, voluminous, watery diarrhea and effortless vomiting, the diarrhea is sometimes referred as “rice water stools”. The incubation period of cholera can range from several hours to 5 days. It causes massive fluid loss by toxin mediated hypersecretion of water and chloride ion. Contaminated food and water is the mode of transmission for this infection. cholerae is traditionally classified by O group (with >150 O types currently recognized in the widely used Sakazaki grouping system) and by biotype (classical and El Tor) and serotype (Ogawa, Inaba, and, rarely, Hikojima). This acute diarrheal illness is caused by certain serotypes of Vibrio Cholerae. Cholera has long been known as a cause of diarrhea.
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